TRACK-CF prospective cohort study: Understanding early cystic fibrosis lung disease.

ABSTRACT:

Background

Lung disease as major cause for morbidity in patients with cystic fibrosis (CF) starts early in life. Its large phenotypic heterogeneity is partially explained by the genotype but other contributing factors are not well delineated. The close relationship between mucus, inflammation and infection, drives morpho-functional alterations already early in pediatric CF disease, The TRACK-CF cohort has been established to gain insight to disease onset and progression, assessed by lung function testing and imaging to capture morpho-functional changes and to associate these with risk and protective factors, which contribute to the variation of the CF lung disease progression.

Methods and design

TRACK-CF is a prospective, longitudinal, observational cohort study following pa

SUBMITTER: Steinke E 

PROVIDER: S-EPMC9853074 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature