Environmental chemicals and endogenous metabolites in bile of USA and Norway patients with primary sclerosing cholangitis.

ABSTRACT: Primary sclerosing cholangitis (PSC) is a complex bile duct disorder. Its etiology is incompletely understood, but environmental chemicals likely contribute to risk. Patients with PSC have an altered bile metabolome, which may be influenced by environmental chemicals. This novel study utilized state-of-the-art high-resolution mass spectrometry (HRMS) with bile samples to provide the first characterization of environmental chemicals and metabolomics (collectively, the exposome) in PSC patients located in the United States of America (USA) (n = 24) and Norway (n = 30). First, environmental chemical- and metabolome-wide association studies were conducted to assess geographic-based similarities and differences in the bile of PSC patients. Nine environmental chemicals (false disco

SUBMITTER: Grant CW 

PROVIDER: S-EPMC9853141 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature