The role of inflammation in acute psychosocial stress-induced modulation of reward processing in healthy female adults.

ABSTRACT:

Background

Anhedonia, or loss of interest and pleasure, is a pernicious symptom of depression that involves deficits in reward processing. Stress-induced inflammation is a plausible biopsychosocial mechanism of reward deficits, but little is known whether stress-induced inflammation alters reward behavior. The present study (a secondary analysis of a completed randomized controlled trial) tested whether acute stress activated a key pro-inflammatory transcription control pathway, NF-κB, and whether this activation was associated with acute stress-induced modulation of reward processing.

Methods

Healthy female adults (age 18-25) were randomized to undergo an acute psychosocial stressor (Trier Social Stress Test; n = 36) or a no-stress active control (n = 16). The

SUBMITTER: Boyle CC 

PROVIDER: S-EPMC9853307 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature