A Kinetic Map of the Influence of Biomimetic Lipid Model Membranes on Aβ₄₂ Aggregation.

ABSTRACT: The aggregation of the amyloid β (Aβ) peptide is one of the molecular hallmarks of Alzheimer's disease (AD). Although Aβ deposits have mostly been observed extracellularly, various studies have also reported the presence of intracellular Aβ assemblies. Because these intracellular Aβ aggregates might play a role in the onset and progression of AD, it is important to investigate their possible origins at different locations of the cell along the secretory pathway of the amyloid precursor protein, from which Aβ is derived by proteolytic cleavage. Senile plaques found in AD are largely composed of the 42-residue form of Aβ (Aβ₄₂). Intracellularly, Aβ₄₂ is produced in the endoplasmatic reticulum (ER) and Golgi apparatus. Since lipid bilayers have been shown to promote the

SUBMITTER: Baumann KN 

PROVIDER: S-EPMC9853501 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature