Hypertension Is Associated With an Earlier Age of Onset of Huntington's Disease.

ABSTRACT:

Background and objective

Hypertension (HTN) is associated with worsening clinical outcomes in neurodegenerative diseases. The relationship between HTN and the age of diagnosis (ADx) of Huntington's disease (HD) is not clear, however. This study sought to determine if the presence of HTN in adult patients with premanifest HD was associated with an earlier ADx compared with normotensive patients with HD.

Methods

Premanifest participants from Enroll-HD were included if they had a cytosine-adenine-guanine greater than or equal to 36, baseline diagnostic confidence level less than 4, baseline total functional capacity score greater than 11, and baseline motor score less than 21. There were 3020 premanifest participants with HD, and 293 reported a diagnosis of HTN. HTN was transfo

SUBMITTER: Schultz JL 

PROVIDER: S-EPMC9853516 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature