Neutrophils drive pulmonary vascular leakage in MHV-1 infection of susceptible A/J mice.

ABSTRACT:

Background

Lung inflammation, neutrophil infiltration, and pulmonary vascular leakage are pathological hallmarks of acute respiratory distress syndrome (ARDS) which can lethally complicate respiratory viral infections. Despite similar comorbidities, however, infections in some patients may be asymptomatic while others develop ARDS as seen with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections for example.

Methods

In this study, we infected resistant C57BL/6 and susceptible A/J strains of mice with pulmonary administration of murine hepatitis virus strain 1 (MHV-1) to determine mechanisms underlying susceptibility to pulmonary vascular leakage in a respiratory coronavirus infection model.

Results

A/J animals displayed increased lung injury paramet

SUBMITTER: Gong HH 

PROVIDER: S-EPMC9853883 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature