Insect PRXamides: Evolutionary Divergence, Novelty, and Loss in a Conserved Neuropeptide System.

ABSTRACT: The PRXamide neuropeptides have been described in both protostome and deuterostome species, including all major groups of the Panarthropoda. Best studied are the insect PRXamides consisting of three genes: pk/pban, capa, and eth, each encoding multiple short peptides that are cleaved post-translationally. Comparisons of genome and transcriptome sequences reveal that while retaining its fundamental ancestral organization, the products of the pk/pban gene have undergone significant change in the insect Order Diptera. Basal dipteran pk/pban genes are much like those of other holometabolous insects, while more crown species have lost two peptide coding sequences including the otherwise ubiquitous pheromone biosynthesis activating neuropeptide (PBAN). In the genomic model species Drosophila mel

SUBMITTER: Farris SM 

PROVIDER: S-EPMC9853942 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature