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Diaminoanthraquinone Enhances Alkaloid Ionization in MALDI-MS.

ABSTRACT: The alkaloids epinastine, 3-methylxanthine and camptothecin were analyzed by matrix-assisted laser desorption/ionization mass spectrometry (MALDI-MS). The ionization efficiencies of epinastine and 3-methylxanthine were improved upon the addition of 1,5-diaminoanthraquinone (DAAQ). DAAQ did not show ultraviolet absorbance peaks at wavelengths around 337 nm and 355 nm that are used in conventional MALDI-MS instruments. In addition, the DAAQ ion peak was very weak relative to those of the analytes due to the low absorbance efficiency. These properties of DAAQ are advantageous for the DAAQ-MALDI-MS analysis of alkaloids.

SUBMITTER: Yamagaki T

PROVIDER: S-EPMC9853952 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature

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Diaminoanthraquinone Enhances Alkaloid Ionization in MALDI-MS.

Yamagaki Tohru T Osawa Tsukiho T

Mass spectrometry (Tokyo, Japan) 20221228 1

The alkaloids epinastine, 3-methylxanthine and camptothecin were analyzed by matrix-assisted laser desorption/ionization mass spectrometry (MALDI-MS). The ionization efficiencies of epinastine and 3-methylxanthine were improved upon the addition of 1,5-diaminoanthraquinone (DAAQ). DAAQ did not show ultraviolet absorbance peaks at wavelengths around 337 nm and 355 nm that are used in conventional MALDI-MS instruments. In addition, the DAAQ ion peak was very weak relative to those of the analytes ...[more]

PMID: 36713806

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Dataset Information

Diaminoanthraquinone Enhances Alkaloid Ionization in MALDI-MS.

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Diaminoanthraquinone Enhances Alkaloid Ionization in MALDI-MS.

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