Effect of urolithin A on the improvement of vascular endothelial function depends on the gut microbiota.

ABSTRACT:

Background

Urolithin A (UA) is a metabolite produced by gut microbiota from ingested ellagic acid. Although the effect of ellagic acid intake on vascular endothelial function (VEF) improvement has been reported, the effect of UA intake on VEF improvement remains obscure. In addition, UA has been reported to improve the intestinal barrier function, and UA may have improved VEF by gut microbiome alteration.

Objective

In this study, we conducted a clinical trial to explore and analyze the effects of UA intake on vascular endothelial function (VEF) and characteristics of the intestinal environment, such as gut microbiome profiling and organic acid composition.

Methods

A placebo-controlled, randomized, double-blinded, parallel group trial was conducted on participants who

SUBMITTER: Nishimoto Y 

PROVIDER: S-EPMC9854132 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature