Scientific opinion on the tolerable upper intake level for selenium.

ABSTRACT: Following a request from the European Commission, the EFSA Panel on Nutrition, Novel Foods and Food Allergens (NDA) was asked to deliver a scientific opinion on the tolerable upper intake level (UL) for selenium. Systematic reviews of the literature were conducted to identify evidence regarding excess selenium intake and clinical effects and potential biomarkers of effect, risk of chronic diseases and impaired neuropsychological development in humans. Alopecia, as an early observable feature and a well-established adverse effect of excess selenium exposure, is selected as the critical endpoint on which to base a UL for selenium. A lowest-observed-adverse-effect-level (LOAEL) of 330 μg/day is identified from a large randomised controlled trial in humans (the Selenium and Vitamin E Cancer Pr

SUBMITTER: EFSA Panel on Nutrition, Novel Foods and Food Allergens (NDA) 

PROVIDER: S-EPMC9854220 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature