Cofactors of drug hypersensitivity-A monocenter retrospective analysis.

ABSTRACT:

Background

Drug hypersensitivity reactions (DHRs) are major medical problems that influence the treatment of patients by both under- and overdiagnosis. Still, little is known about the role of predisposing or protecting cofactors of DHR.

Objective

This study aims to determine drug-specific cofactors in patients with DHR.

Methods

Retrospective file chart analysis of inpatients with suspected DHR in our department between 2015 and 2020 was performed. Descriptive statistics and multiple logistic regression were conducted for the estimation and statistical interference.

Results

DHRs were suspected in 393 patients with 678 culprit drugs. In 183 cases, drug hypersensitivities were confirmed, mostly against nonopioid analgesic drugs and antibiotics. Multiple logistic

SUBMITTER: Kuhl J 

PROVIDER: S-EPMC9854260 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature