Glioma-derived CCL2 and CCL7 mediate migration of immune suppressive CCR2⁺/CX3CR1⁺ M-MDSCs into the tumor microenvironment in a redundant manner.

ABSTRACT: Glioblastoma (GBM) is the most common and malignant primary brain tumor, resulting in poor survival despite aggressive therapies. GBM is characterized in part by a highly heterogeneous and immunosuppressive tumor microenvironment (TME) made up predominantly of infiltrating peripheral immune cells. One significant immune cell type that contributes to glioma immune evasion is a population of immunosuppressive, hematopoietic cells, termed myeloid-derived suppressor cells (MDSCs). Previous studies suggest that a potent subset of myeloid cells, expressing monocytic (M)-MDSC markers, distinguished by dual expression of chemokine receptors CCR2 and CX3CR1, utilize CCR2 to infiltrate into the TME. This study evaluated the T cell suppressive function and migratory properties of CCR2⁺/CX3

SUBMITTER: Takacs GP 

PROVIDER: S-EPMC9854274 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature