Seleno-Analogs of Scaffolds Resembling Natural Products a Novel Warhead toward Dual Compounds.

ABSTRACT: Nowadays, oxidative cell damage is one of the common features of cancer and Alzheimer's disease (AD), and Se-containing molecules, such as ebselen, which has demonstrated strong antioxidant activity, have demonstrated well-established preventive effects against both diseases. In this study, a total of 39 Se-derivatives were synthesized, purified, and spectroscopically characterized by NMR. Antioxidant ability was tested using the DPPH assay, while antiproliferative activity was screened in breast, lung, prostate, and colorectal cancer cell lines. In addition, as a first approach to evaluate their potential anti-Alzheimer activity, the in vitro acetylcholinesterase inhibition (AChEI) was tested. Regarding antioxidant properties, compound 13a showed concentration- and time-dependent r

SUBMITTER: Astrain-Redin N 

PROVIDER: S-EPMC9854712 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature