Preoperative oral fluoroquinolone antibiotics in elective colorectal surgery to prevent surgical site infections: a systematic review and meta-analysis.

ABSTRACT:

Background

Preoperative treatment with oral neomycin combined with erythromycin or metronidazole is recommended to decrease the risk of surgical site infections (SSIs) in elective colorectal surgery. However, oral neomycin is not commercially available in Canada, and therefore it is not routinely used. Fluoroquinolones are widely available and have excellent activity against aerobic Gram-negative bacteria. The aim of this systematic review was to identify, critically appraise and summarize the evidence on the efficacy and safety of preoperative use of oral fluoroquinolone antibiotics for the prevention of SSIs in adult patients undergoing elective colorectal resection.

Methods

Following Cochrane guidelines, we included English-language randomized controlled trials (RCTs) com

SUBMITTER: Johnson G 

PROVIDER: S-EPMC9854941 | biostudies-literature | 2023 Jan-Feb

REPOSITORIES: biostudies-literature