IL-21, Inflammatory Cytokines and Hyperpolarized CD8⁺ T Cells Are Central Players in Lupus Immune Pathology.

ABSTRACT: Systemic lupus erythematous (SLE) is a chronic autoimmune disorder, broadly characterized by systemic inflammation along with heterogeneous clinical manifestations, severe morbidity, moribund organ failure and eventual mortality. In our study, SLE patients displayed a higher percentage of activated, inflamed and hyper-polarized CD8⁺ T cells, dysregulated CD8⁺ T cell differentiation, significantly elevated serum inflammatory cytokines and higher accumulation of cellular ROS when compared to healthy controls. Importantly, these hyper-inflammatory/hyper-polarized CD8⁺ T cells responded better to an antioxidant than to an oxidant. Terminally differentiated Tc1 cells also showed plasticity upon oxidant/antioxidant treatment, but that was in contrast to the SLE C

SUBMITTER: Sengupta S 

PROVIDER: S-EPMC9855022 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature