Hypoxia Affects the Antioxidant Activity of Glutaredoxin 3 in Scylla paramamosain through Hypoxia Response Elements.

ABSTRACT: Hypoxia is a major environmental stressor that can damage the oxidation metabolism of crustaceans. Glutaredoxin (Grx) is a key member of the thioredoxin superfamily and plays an important role in the host's defense against oxidative stress. At present, the role of Grx in response to hypoxia in crustaceans remains unclear. In this study, the full-length cDNA of Grx3 (SpGrx3) was obtained from the mud crab Scylla paramamosain, which contains a 129-bp 5' untranslated region, a 981-bp open reading frame, and a 1,183-bp 3' untranslated region. The putative SpGrx3 protein contains an N-terminal thioredoxin domain and two C-terminal Grx domains. SpGrx3 was expressed in all tissues examined, with the highest expression in the anterior gills. After hypoxia, SpGrx3 expres

SUBMITTER: Jie YK 

PROVIDER: S-EPMC9855028 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature