Nootkatone Supplementation Ameliorates Carbon Tetrachloride-Induced Acute Liver Injury via the Inhibition of Oxidative Stress, NF-κB Pathways, and the Activation of Nrf2/HO-1 Pathway.

ABSTRACT: Acute liver injury is a type of liver diseases, and it has raised concerns worldwide due to the lack of effective therapies. The aim of this study is to investigate the protective effects of nootkatone (NOOT) on carbon tetrachloride (CCl₄)-caused acute liver injury in mice. Mice were randomly divided into control, CCl₄ model, NOOT, and NOOT (5, 10, and 20 mg/kg/day) plus CCl₄ groups, respectively. Mice in the CCl₄ plus NOOT groups were orally administrated with NOOT at 5, 10, and 20 mg/kg/days for seven days prior to 0.3% CCl₄ injection at 10 mL/kg body weight, respectively. Our results showed that NOOT supplementation significantly ameliorated CCl₄-induced increases of serum AST and ALT levels, hepatocyte necrosis, inflamma

SUBMITTER: Dai C 

PROVIDER: S-EPMC9855146 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature