Mice Placental ECM Components May Provide A Three-Dimensional Placental Microenvironment.

ABSTRACT: Bioethical limitations impair deeper studies in human placental physiology, then most studies use human term placentas or murine models. To overcome these challenges, new models have been proposed to mimetize the placental three-dimensional microenvironment. The placental extracellular matrix plays an essential role in several processes, being a part of the establishment of materno-fetal interaction. Regarding these aspects, this study aimed to investigate term mice placental ECM components, highlighting its collagenous and non-collagenous content, and proposing a potential three-dimensional model to mimetize the placental microenvironment. For that, 18.5-day-old mice placenta, both control and decellularized (n = 3 per group) were analyzed on Orbitrap Fusion Lumos spectrometer (The

SUBMITTER: Barreto RDSN 

PROVIDER: S-EPMC9855196 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature