Therapeutic Effects of Butyrate on Pediatric Obesity: A Randomized Clinical Trial.

ABSTRACT:

Importance

The pediatric obesity disease burden imposes the necessity of new effective strategies.

Objective

To determine whether oral butyrate supplementation as an adjunct to standard care is effective in the treatment of pediatric obesity.

Design, setting, and participants

A randomized, quadruple-blind, placebo-controlled trial was performed from November 1, 2020, to December 31, 2021, at the Tertiary Center for Pediatric Nutrition, Department of Translational Medical Science, University of Naples Federico II, Naples, Italy. Participants included children aged 5 to 17 years with body mass index (BMI) greater than the 95th percentile.

Interventions

Standard care for pediatric obesity supplemented with oral sodium butyrate, 20 mg/kg body weight per day, or pla

SUBMITTER: Coppola S 

PROVIDER: S-EPMC9855301 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature