Epigenetic Clock Explains White Matter Hyperintensity Burden Irrespective of Chronological Age.

ABSTRACT: In this manuscript we studied the relationship between WMH and biological age (B-age) in patients with acute stroke. We included in this study 247 patients with acute stroke recruited at Hospital del Mar having both epigenetic (DNA methylation) and magnetic resonance imaging data. WMH were measured using a semi-automated method. B-age was calculated using two widely used methods: the Hannum and Horvath formulas. We used multiple linear regression models to interrogate the role of B-age on WMH volume after adjusting for chronological age (C-age) and other covariables. Average C-age of the sample was 68.4 (±11.8) and we observed a relatively high median WMH volume (median = 8.8 cm³, Q1-Q3 = 4.05-18.8). After adjusting for potential confounders, we observed a significant effect of

SUBMITTER: Jimenez-Balado J 

PROVIDER: S-EPMC9855342 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature