CRABP-I Expression Patterns in the Developing Chick Inner Ear.

ABSTRACT: The vertebrate inner ear is a complex three-dimensional sensorial structure with auditory and vestibular functions, regarded as an excellent system for analyzing events that occur during development, such as patterning, morphogenesis, and cell specification. Retinoic acid (RA) is involved in all these development processes. Cellular retinoic acid-binding proteins (CRABPs) bind RA with high affinity, buffering cellular free RA concentrations and consequently regulating the activation of precise specification programs mediated by particular regulatory genes. In the otic vesicle, strong CRABP-I expression was detected in the otic wall's dorsomedial aspect, where the endolymphatic apparatus develops, whereas this expression was lower in the ventrolateral aspect, where part of the audito

SUBMITTER: Cardena-Nunez S 

PROVIDER: S-EPMC9855850 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature