A Computer Simulation of SARS-CoV-2 Mutation Spectra for Empirical Data Characterization and Analysis.

ABSTRACT: It is very important to compute the mutation spectra, and simulate the intra-host mutation processes by sequencing data, which is not only for the understanding of SARS-CoV-2 genetic mechanism, but also for epidemic prediction, vaccine, and drug design. However, the current intra-host mutation analysis algorithms are not only inaccurate, but also the simulation methods are unable to quickly and precisely predict new SARS-CoV-2 variants generated from the accumulation of mutations. Therefore, this study proposes a novel accurate strand-specific SARS-CoV-2 intra-host mutation spectra computation method, develops an efficient and fast SARS-CoV-2 intra-host mutation simulation method based on mutation spectra, and establishes an online analysis and visualization platform. Our main results incl

SUBMITTER: Xiao M 

PROVIDER: S-EPMC9855923 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature