Identification and Verification of Biomarkers and Immune Infiltration in Obesity-Related Atrial Fibrillation.

ABSTRACT: Obesity is an independent risk factor for atrial fibrillation (AF). However, the mechanisms underlying this crosstalk are still being uncovered. Co-differentially expressed genes (co-DEGs) of AF and obesity microarrays were identified by bioinformatics analysis. Subsequently, functional enrichment, cell-type enrichment, and protein-protein interaction network analyses of co-DEGs were carried out. Then, we validated the hub genes by qRT-PCR of patients' blood samples. Finally, CIBERSORT was utilized to evaluate the AF microarray to determine immune infiltration and the correlation between validated hub genes and immune cells. A total of 23 co-up-regulated DEGs in AF and obesity microarrays were identified, and these genes were enriched in inflammation- and immune-related function. The enric

SUBMITTER: Xie Z 

PROVIDER: S-EPMC9855995 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature