The Missing Pieces: The Role of Secretion Systems in Campylobacter jejuni Virulence.

ABSTRACT: Campylobacter jejuni is likely the most common bacterial cause of gastroenteritis worldwide, responsible for millions of cases of inflammatory diarrhea characterized by severe abdominal cramps and blood in the stool. Further, C. jejuni infections are associated with post-infection sequelae in developed countries and malnutrition and growth-stunting in low- and middle-income countries. Despite the increasing prevalence of the disease, campylobacteriosis, and the recognition that this pathogen is a serious health threat, our understanding of C. jejuni pathogenesis remains incomplete. In this review, we focus on the Campylobacter secretion systems proposed to contribute to host-cell interactions and survival in the host. Moreover, we have applied a genomics approac

SUBMITTER: Gabbert AD 

PROVIDER: S-EPMC9856085 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature