New Opportunities in Heart Failure with Preserved Ejection Fraction: From Bench to Bedside… and Back.

ABSTRACT: Heart failure with preserved ejection fraction (HFpEF) is a growing public health problem in nearly 50% of patients with heart failure. Therefore, research on new strategies for its diagnosis and management has become imperative in recent years. Few drugs have successfully improved clinical outcomes in this population. Therefore, numerous attempts are being made to find new pharmacological interventions that target the main mechanisms responsible for this disease. In recent years, pathological mechanisms such as cardiac fibrosis and inflammation, alterations in calcium handling, NO pathway disturbance, and neurohumoral or mechanic impairment have been evaluated as new pharmacological targets showing promising results in preliminary studies. This review aims to analyze the new strategies an

SUBMITTER: Parra-Lucares A 

PROVIDER: S-EPMC9856156 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature