Intestinal Barrier Dysfunction and Microbial Translocation in Patients with First-Diagnosed Atrial Fibrillation.

ABSTRACT:

Background

According to the leaky gut concept, microbial products (e.g., lipopolysaccharide, LPS) enter the circulation and mediate pro-inflammatory immunological responses. Higher plasma LPS levels have been reported in patients with various cardiovascular diseases, but not specifically during early atrial fibrillation (AF).

Methods

We studied data and blood samples from patients presenting with first-diagnosed AF (FDAF) (n = 80) and 20 controls.

Results

Circulating biomarkers that are suggestive of mucosal inflammation (zonulin, mucosal adhesion molecule MAdCAM-1) and intestinal epithelium damage (intestinal fatty acid binding protein, IFABP) were increased in the plasma of patients with FDAF when compared to patients with chronic cardiovascular diseases but

SUBMITTER: Blobaum L 

PROVIDER: S-EPMC9856173 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature