Incidence of and Neurodevelopmental Outcomes After Late-Onset Meningitis Among Children Born Extremely Preterm.

ABSTRACT:

Importance

Late-onset meningitis (LOM) has been associated with adverse neurodevelopmental outcomes in children born extremely preterm.

Objective

To report the incidence of LOM during birth hospitalization and neurodevelopmental outcomes at 18 to 26 months' corrected age.

Design, setting, and participants

This cohort study is a secondary analysis of a multicenter prospective cohort of children born at 22 to 26 weeks' gestation between 2003 and 2017 with follow-up from 2004 to 2021. The study was conducted at 25 Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network centers.

Exposures

Culture-confirmed LOM.

Main outcomes and measures

Incidence and microbiology of LOM (2003-2017); lumbar puncture (LP) perf

SUBMITTER: Brumbaugh JE 

PROVIDER: S-EPMC9856224 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature