Effectiveness of Fecal Microbiota Transplantation for Weight Loss in Patients With Obesity Undergoing Bariatric Surgery: A Randomized Clinical Trial.

ABSTRACT:

Importance

Severe obesity is a major health concern. However, a few patients remain resistant to bariatric surgery and other treatments. Animal studies suggest that weight may be altered by fecal microbiota transplantation (FMT) from a lean donor.

Objective

To determine whether FMT from a lean donor reduces body weight and further improves the results of bariatric surgery.

Design, setting, and participants

This double-blinded, placebo-controlled, multicenter, randomized clinical trial was conducted in 2018 to 2021 among adult individuals with severe obesity treated at 2 bariatric surgery centers in Finland and included 18 months of follow-up. Patients eligible for bariatric surgery were recruited for the study. Data were analyzed from March 2021 to May 2022.

Interv

SUBMITTER: Lahtinen P 

PROVIDER: S-EPMC9856235 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature