Estimated BNT162b2 Vaccine Effectiveness Against Infection With Delta and Omicron Variants Among US Children 5 to 11 Years of Age.

ABSTRACT:

Importance

Data describing the vaccine effectiveness (VE) and durability of BNT162b2 among children 5 to 11 years of age are needed.

Objective

To estimate BNT162b2 VE against SARS-CoV-2 infection among children aged 5 to 11 years during Delta and Omicron variant-predominant periods and to further assess VE according to prior SARS-CoV-2 infection status and by sublineage during the Omicron variant-predominant period.

Design, setting, and participants

This test-negative case-control study was conducted from November 2 to December 9, 2021 (Delta variant), and from January 16 to September 30, 2022 (Omicron variant), among 160 002 children tested at a large national US retail pharmacy chain, for SARS-CoV-2 via polymerase chain reaction (PCR); 62 719 children were tested du

SUBMITTER: Khan FL 

PROVIDER: S-EPMC9856252 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature