The Role of Pharmacotherapy in Treatment of Meningioma: A Systematic Review.

ABSTRACT: The safety and efficacy of various pharmacotherapeutic regimens on refractory meningiomas have been the focus of investigations. We present a comprehensive review of the previous efforts and the current state of ongoing clinical trials. A PRISMA-compliant review of the MEDLINE and ClinicalTrial.gov databases of the National Library of Medicine were performed. The primary outcomes of interest for included articles were radiographic response, overall survival, progression-free survival, six-month progression-free survival, and adverse events. Overall, 34 completed trials and 27 ongoing clinical trials were eligible. Six-month progression-free survival was reported in 6-100% of patients in the completed studies. Hematological disorders were the most common adverse events. Of the ongoing clini

SUBMITTER: Shahbandi A 

PROVIDER: S-EPMC9856307 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature