Transferability of Alzheimer Disease Polygenic Risk Score Across Populations and Its Association With Alzheimer Disease-Related Phenotypes.

ABSTRACT:

Importance

Polygenic risk scores (PRSs), which aggregate the genetic effects of single-nucleotide variants identified in genome-wide association studies (GWASs), can help distinguish individuals at a high genetic risk for Alzheimer disease (AD). However, genetic studies have predominantly focused on populations of European ancestry.

Objective

To evaluate the transferability of a PRS for AD in the Korean population using summary statistics from a prior GWAS of European populations.

Design, setting, and participants

This cohort study developed a PRS based on the summary statistics of a large-scale GWAS of a European population (the International Genomics of Alzheimer Project; 21 982 AD cases and 41 944 controls). This PRS was tested for an association with AD dementia a

SUBMITTER: Jung SH 

PROVIDER: S-EPMC9856322 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature