Association of Linezolid With Risk of Serotonin Syndrome in Patients Receiving Antidepressants.

ABSTRACT:

Importance

Linezolid has the potential to interact with some antidepressants, leading to serotonin syndrome. However, few empirical data support warnings for patients taking antidepressants to avoid linezolid.

Objectives

To examine the incidence of serotonin syndrome in patients receiving oral linezolid and how concomitant antidepressant treatment changes this risk.

Design, setting, and participants

This population-based, retrospective cohort study used linked administrative databases at ICES to collect data from outpatients 66 years or older in Ontario, Canada, who were prescribed oral linezolid for any duration from October 1, 2014, to January 1, 2021, with follow-up to 30 days (January 31, 2021).

Exposures

The use of antidepressants while receiving linezolid

SUBMITTER: Bai AD 

PROVIDER: S-EPMC9856528 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature