Association of New Use of Antihypertensives That Stimulate vs Inhibit Type 2 and 4 Angiotensin II Receptors With Dementia Among Medicare Beneficiaries.

ABSTRACT:

Importance

Prevalent use of antihypertensive medications that stimulate type 2 and 4 angiotensin II receptors, compared with those that do not stimulate these receptors, has been associated with a lower risk of dementia. However, previous studies were limited by inclusion of individuals with prevalent hypertension and a history of antihypertensive use prior to the start of the study, which can introduce bias.

Objective

To examine the association of new use of antihypertensive medication regimens that stimulate vs inhibit type 2 and 4 angiotensin II receptors with Alzheimer disease and related dementias (ADRD) among Medicare beneficiaries.

Design, setting, and participants

This cohort study was conducted among 57 773 Medicare fee-for-service beneficiaries (January 1, 2

SUBMITTER: Marcum ZA 

PROVIDER: S-EPMC9856661 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature