Association Between Proton Pump Inhibitor Use During Early Pregnancy and Risk of Congenital Malformations.

ABSTRACT:

Importance

Proton pump inhibitors (PPIs) are increasingly used during pregnancy; however, several observational studies have raised concerns about an increased risk of specific types of congenital malformations.

Objective

To examine the association between PPI exposure during early pregnancy and the risk of congenital malformations.

Design, setting, and participants

This population-based cohort study used data from the National Health Insurance Service-National Health Information Database of South Korea (2010-2020); sibling-controlled analyses were conducted to account for familial factors. A total of 2 696 216 pregnancies in women aged 19 to 44 years between June 1, 2011, and December 31, 2019, and their live-born infants were identified. Pregnant women who were expo

SUBMITTER: Choi A 

PROVIDER: S-EPMC9856708 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature