Preclinical Characterisation of PSMA/GRPR-Targeting Heterodimer [⁶⁸Ga]Ga-BQ7812 for PET Diagnostic Imaging of Prostate Cancer: A Step towards Clinical Translation.

ABSTRACT: The development of radioligands targeting prostate-specific membrane antigen (PSMA) and gastrin-releasing peptide receptor (GRPR) has shown promising results for the imaging and therapy of prostate cancer. However, studies have shown that tumors and metastases can express such targets heterogeneously. To overcome this issue and to improve protein binding, radioligands with the ability to bind both PSMA and GRPR have been developed. Herein, we present the preclinical characterization of [⁶⁸Ga]Ga-BQ7812; a PSMA/GRPR-targeting radioligand for the diagnostic PET imaging of prostate cancer. This study aimed to evaluate [⁶⁸Ga]Ga-BQ7812 to promote the translation of such imaging probes into the clinic. [⁶⁸Ga]Ga-BQ7812 demonstrated rapid and specific binding to bot

SUBMITTER: Lundmark F 

PROVIDER: S-EPMC9856709 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature