Effect of Remifentanil vs Neuromuscular Blockers During Rapid Sequence Intubation on Successful Intubation Without Major Complications Among Patients at Risk of Aspiration: A Randomized Clinical Trial.

ABSTRACT:

Importance

It is uncertain whether a rapid-onset opioid is noninferior to a rapid-onset neuromuscular blocker during rapid sequence intubation when used in conjunction with a hypnotic agent.

Objective

To determine whether remifentanil is noninferior to rapid-onset neuromuscular blockers for rapid sequence intubation.

Design, setting, and participants

Multicenter, randomized, open-label, noninferiority trial among 1150 adults at risk of aspiration (fasting for <6 hours, bowel occlusion, recent trauma, or severe gastroesophageal reflux) who underwent tracheal intubation in the operating room at 15 hospitals in France from October 2019 to April 2021. Follow-up was completed on May 15, 2021.

Interventions

Patients were randomized to receive neuromuscular blockers (

SUBMITTER: Grillot N 

PROVIDER: S-EPMC9856823 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature