Identification of potential antigenic peptides of Brucella through proteome and peptidome.

ABSTRACT:

Background

Brucellosis, caused by Brucella spp., is a major zoonotic public health threat. Although several Brucella vaccines have been demonstrated for use in animals, Brucella spp. can cause human infection and to date, there are no human-use vaccines licensed by any agency. Recently, methods in vaccine informatics have made major breakthroughs in peptide-based epitopes, opening up a new avenue of vaccine development.

Objectives

The purpose of this article was to identify potential antigenic peptides in Brucella by proteome and peptidome analyses.

Methods

Mouse infection models were first established by injection with Brucella and spleen protein profiles were then analysed. Subsequently, the major histocompatibility complex class I or II (major histocompatibility co

SUBMITTER: Pei M 

PROVIDER: S-EPMC9856995 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature