Association of 5α-Reductase Inhibitors With Dementia, Depression, and Suicide.

ABSTRACT:

Importance

In recent decades, there has been increased interest in the possible adverse neurological effects of 5α-reductase inhibitors (5-ARIs), which have been used mainly for benign prostatic hyperplasia and androgenic alopecia. Numerous studies and reports have indicated associations of 5-ARIs with depression and suicide. However, most of these studies had methodological shortcomings, and very little is known about the potential association of 5-ARIs with dementia.

Objective

To investigate the association of 5-ARI use with all-cause dementia, Alzheimer disease, vascular dementia, depression, and suicide.

Design, setting, and participants

This Swedish register-based cohort study included 2 236 876 men aged 50 to 90 years between July 1, 2005, and December 31, 2018.

SUBMITTER: Garcia-Argibay M 

PROVIDER: S-EPMC9857015 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature