Association Between Antiepileptic Drugs and Incident Parkinson Disease.

ABSTRACT:

Importance

Recent studies have highlighted an association between epilepsy and Parkinson disease (PD). The role of antiepileptic drugs (AEDs) has not been explored.

Objective

To investigate the association between AEDs and incident PD.

Design, setting, and participants

This nested case-control study started collecting data from the UK Biobank (UKB) in 2006, and data were extracted on June 30, 2021. Individuals with linked primary care prescription data were included. Cases were defined as individuals with a Hospital Episode Statistics (HES)-coded diagnosis of PD. Controls were matched 6:1 for age, sex, race and ethnicity, and socioeconomic status. Prescription records were searched for AEDs prescribed prior to diagnosis of PD. The UKB is a longitudinal cohort study wi

SUBMITTER: Belete D 

PROVIDER: S-EPMC9857018 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature