A Comprehensive Study on the Electrostatic Properties of Tubulin-Tubulin Complexes in Microtubules.

ABSTRACT: Microtubules are key players in several stages of the cell cycle and are also involved in the transportation of cellular organelles. Microtubules are polymerized by α/β tubulin dimers with a highly dynamic feature, especially at the plus ends of the microtubules. Therefore, understanding the interactions among tubulins is crucial for characterizing microtubule dynamics. Studying microtubule dynamics can help researchers make advances in the treatment of neurodegenerative diseases and cancer. In this study, we utilize a series of computational approaches to study the electrostatic interactions at the binding interfaces of tubulin monomers. Our study revealed that among all the four types of tubulin-tubulin binding modes, the electrostatic attractive interactions in the α/β tubulin binding a

SUBMITTER: Guo W 

PROVIDER: S-EPMC9857020 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature