Baseline [⁶⁸Ga]Ga-PSMA-11 PET/CT before [¹⁷⁷Lu]Lu-PSMA-617 Radioligand Therapy: Value of PSMA-Uptake Thresholds in Predicting Targetable Lesions.

ABSTRACT: Baseline uptake on prostate-specific membrane antigen (PSMA)-targeted imaging is a prerequisite for radioligand therapy (RLT) with [¹⁷⁷Lu]Lu-PSMA-617. This study aims to quantify lesion-based response to RLT in relation to pretreatment standard molecular imaging metrics derived from [⁶⁸Ga]Ga-PSMA-11 PET/CT. Sixty-one patients with mCRPC underwent [⁶⁸Ga]Ga-PSMA-11 PET/CT imaging before and after a median of 4 (IQR 2-6) RLT cycles. Maximum and mean standardized uptake values (SUV_max, SUV_mean), as well as tumor-to-liver ratio (TLR), were assessed. A median of 12 (IQR 7-17) lesions was analyzed per patient, resulting in a total of 718 lesions. Lesions with ≥30% SUV_max decline or falling below the blood pool uptake were considere

SUBMITTER: Groener D 

PROVIDER: S-EPMC9857048 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature