In Vitro Antiviral Evaluations of Coldmix^®: An Essential Oil Blend against SARS-CoV-2.

ABSTRACT: Coldmix^® is a commercially available Eucalyptus aetheroleum and, Abies aetheroleum blend for medicinal applications. In this present study, the in vitro antiviral potential of Coldmix^®, and its major constituents 1,8-cineole and α-pinene were evaluated by using the in vitro ACE2 enzyme inhibition assay as well as the direct contact test against SARS-CoV-2. The observed ACE2 enzyme inhibitory activity of Coldmix^®, 1,8-cineole, and α-pinene were 72%, 88%, and 80%, respectively; whereas in the direct contact test in the vapor phase, the destruction of the virus was 79.9% within 5 min and 93.2% in the 30th min, respectively. In a similar Coldmix^® vapor phase setup using the in vitro cytotoxicity cell assay, E6 VERO healthy cells were ex

SUBMITTER: Baser KHC 

PROVIDER: S-EPMC9857070 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature