Evaluation of zoledronate for the treatment of canine stage III osteosarcoma: A phase II study.

ABSTRACT:

Background

Greater than 90% of dogs with appendicular osteosarcoma will develop pulmonary metastasis despite the standard of care. Available treatments have limited efficacy for stage III disease. Zoledronate, a bisphosphonate, induces apoptosis of canine osteosarcoma cells and appears to modulate the tumour microenvironment.

Objectives

This prospective, single institutional phase IIa trial investigated the use of single agent zoledronate in dogs with pulmonary metastases from osteosarcoma.

Methods

Zoledronate was administered once monthly, and thoracic radiographs were used to assess response.

Results

Eleven dogs were enrolled. Stable disease was achieved in two of eight dogs available for response assessment. The median progression-free survival was 28 days (

SUBMITTER: Smith AA 

PROVIDER: S-EPMC9857128 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature