Effect of Saline vs Gluconate/Acetate-Buffered Solution vs Lactate-Buffered Solution on Serum Chloride Among Children in the Pediatric Intensive Care Unit: The SPLYT-P Randomized Clinical Trial.

ABSTRACT:

Importance

Most children admitted to pediatric intensive care units (PICUs) receive intravenous fluids. A recent systematic review suggested mortality benefit in critically ill adults treated with balanced solutions compared with sodium chloride, 0.9% (saline). There is a lack of clinically directive data on optimal fluid choice in critically ill children.

Objective

To determine if balanced solutions decrease the rise of plasma chloride compared with saline, 0.9%, in critically ill children.

Design, setting, and participants

This single-center, 3-arm, open-label randomized clinical trial took place in a 36-bed PICU. Children younger than 16 years admitted to the PICU and considered to require intravenous fluid therapy by the treating clinician were eligible. Children

SUBMITTER: Raman S 

PROVIDER: S-EPMC9857166 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature