Gradient Magnetic Field Accelerates Division of <i>E. coli</i> Nissle 1917.

ABSTRACT: Cell-cycle progression is regulated by numerous intricate endogenous mechanisms, among which intracellular forces and protein motors are central players. Although it seems unlikely that it is possible to speed up this molecular machinery by applying tiny external forces to the cell, we show that magnetic forcing of magnetosensitive bacteria reduces the duration of the mitotic phase. In such bacteria, the coupling of the cell cycle to the splitting of chains of biogenic magnetic nanoparticles (BMNs) provides a biological realization of such forcing. Using a static gradient magnetic field of a special spatial configuration, in probiotic bacteria E. coli Nissle 1917, we shortened the duration of the mitotic phase and thereby accelerated cell division. Thus, focused magnetic gradient fo

SUBMITTER: Gorobets S 

PROVIDER: S-EPMC9857180 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature