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Abnormalities of EEG Functional Connectivity and Effective Connectivity in Children with Autism Spectrum Disorder.

ABSTRACT: Autism spectrum disorder (ASD) is a heterogeneous neurodevelopmental disorder that interferes with normal brain development. Brain connectivity may serve as a biomarker for ASD in this respect. This study enrolled a total of 179 children aged 3-10 years (90 typically developed (TD) and 89 with ASD). We used a weighted phase lag index and a directed transfer function to investigate the functional and effective connectivity in children with ASD and TD. Our findings indicated that patients with ASD had local hyper-connectivity of brain regions in functional connectivity and simultaneous significant decrease in effective connectivity across hemispheres. These connectivity abnormalities may help to find biomarkers of ASD.

SUBMITTER: Geng X

PROVIDER: S-EPMC9857308 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature

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Abnormalities of EEG Functional Connectivity and Effective Connectivity in Children with Autism Spectrum Disorder.

Geng Xinling X Fan Xiwang X Zhong Yiwen Y Casanova Manuel F MF Sokhadze Estate M EM Li Xiaoli X Kang Jiannan J

Brain sciences 20230112 1

Autism spectrum disorder (ASD) is a heterogeneous neurodevelopmental disorder that interferes with normal brain development. Brain connectivity may serve as a biomarker for ASD in this respect. This study enrolled a total of 179 children aged 3-10 years (90 typically developed (TD) and 89 with ASD). We used a weighted phase lag index and a directed transfer function to investigate the functional and effective connectivity in children with ASD and TD. Our findings indicated that patients with ASD ...[more]

PMID: 36672111

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