Association of PCSK9 Loss-of-Function Variants With Risk of Heart Failure.

ABSTRACT:

Importance

An animal (mouse) study indicated that deficiency of proprotein convertase subtilisin/kexin type 9 (PCSK9) causes cardiac remodeling and heart failure (HF). Cardiac remodeling after PCSK9-inhibitor treatment is a concern for patients and for development of treatment directed against PCSK9.

Objective

To determine whether genetic variants in the PCSK9 gene are associated with altered cardiac structure, cardiac function, and HF in humans.

Design, setting, participants

This was a nested case-control study within the UK Biobank. Between March 13, 2006, and October 1, 2010, the UK Biobank enrolled 502 480 individuals aged 40 to 69 years. This study focused on a subset of those individuals, who completed cardiac magnetic resonance (CMR) imaging and had available g

SUBMITTER: Trudso LC 

PROVIDER: S-EPMC9857345 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature