Assessment of Body Mass Index, Polygenic Risk Score, and Development of Colorectal Cancer.

ABSTRACT:

Importance

Excess weight, the prevalence of which is high and increasing in many countries, is linked to multiple adverse health outcomes, including increased colorectal cancer (CRC) risk. Better communication of health risks associated with excess weight might support efforts of prevention.

Objective

To evaluate the individual and joint associations of body mass index (BMI) and polygenic risk with CRC, to assess potential interactions among them, and to quantify by how much increased polygenic risk for CRC can be offset by having a BMI within reference range.

Design, setting, and participants

This population-based case-control study was conducted in the Rhine-Neckar region of southwest Germany, with recruitment from 2003 to 2017. Participants with both risk factor an

SUBMITTER: Chen X 

PROVIDER: S-EPMC9857417 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature