Acute Oral Toxicity and Genotoxicity Test and Evaluation of Cinnamomum camphora Seed Kernel Oil.

ABSTRACT: Cinnamomum camphora seed kernel oil (CCSKO) is one of the important natural medium chain triglycerides (MCT) resources, with more than 95.00% of medium chain fatty acids found in the world, and has various physiological effects. However, CCSKO has not been generally recognized as a safe oil or new food resource yet. The acute oral toxicity test and a standard battery of genotoxicity tests (mammalian erythrocyte micronucleus test, Ames test, and in vitro mammalian cell TK gene mutation test) of CCSKO as a new edible plant oil were used in the study. The results of the acute oral toxicity test showed that CCSKO was preliminary non-toxic, with an LD₅₀ value higher than 21.5 g/kg body weight. In the mammalian erythrocyte micronucleus test, there was no concentration-response

SUBMITTER: Wang P 

PROVIDER: S-EPMC9857420 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature