Analysis of Rates of Completion, Delays, and Participant Recruitment in Randomized Clinical Trials in Surgery.

ABSTRACT:

Importance

Discontinuation and nonpublication are established sources of avoidable waste among surgical trials, but rates of delayed completion and recruiting shortfalls remain unclear.

Objectives

To examine the rate of delayed completion, incomplete enrollment, and discontinuation among randomized clinical trials in surgical populations and the duration of delays and extent of recruiting shortfalls among these trials.

Design, setting, and participants

This cross-sectional study examined randomized clinical trials in surgical populations registered on ClinicalTrials.gov between January 1, 2010, and December 31, 2014. Analysis was conducted between October 27, 2021, and June 30, 2022.

Main outcomes and measures

The main outcomes were the percentages of trials co

SUBMITTER: Shadbolt C 

PROVIDER: S-EPMC9857498 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature